#5646
BizHawk is a free and open-source multi-system universal emulator written in C#. Its goal is to eventually simulate all game consoles, and already supports FC, MD, GBA, SFC, SMS, NES, SNES, N64, PC Engine, SS, PS, PSP, and so on more than 10 game consoles. It comes with the professional TAS functions while taking the ease of use into account. That said, BizHawk not only can be used for game clearance video production with TAS, but also is friendly for casual gaming.

#5616
Mednafen (short for My Emulator Doesn't Need A Frickin' Excellent Name, formerly known as Nintencer) is a free, open-source and multi-system video game console emulator for Windows, Mac and Linux platforms. It already emulates nearly 20 home and handheld game consoles from Atari to PS1 era, such as FC, MD, GB, GBA, PS, SS, PC-FX, etc.

#5158
OpenEmu (formerly called OpenNestopia) is a free and open-source multiple systems universal game console emulator only for Mac OS. Its appearance means that the 'It just works' concept has extended to the video game simulation field on Mac operating system for the first time ever. And its purpose is to bring macOS game emulation into the realm of first class citizenship.

#4604
In the past, to play a game for some platform on a computer, you have to find a corresponding console emulator to run it, and the necessary settings of each emulator vary. Some are very simple, while others may be more complex. This can be troublesome even for video game lovers who are fond of doing things from side to side. Fortunately, the appearance of RetroArch makes it more convenient for playing the classic video games on various platforms (a wide range of computers and game consoles) - within the same, lick and friendly GUI, as well as unified settings (so all configuration will be done once and for all).